CELL MIGRATION · Identification and characterization of novel genes regulating cell migration
6РП — Действия „Мария Кюри“
- Период
- 2006-07-01 → 2007-07-31
- Финансиране от ЕС
- 149 722 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Генните механизми, които контролират движението на клетките, се изучават чрез наблюдение на плодови мухи. Разбирането на тези процеси помага да се разбере как туморните клетки се разпространяват в организма и създават метастази.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - CELL MIGRATION (Identification and characterisation of novel genes regulating cell migration)
Cell migration occurs during development of multicellular organisms, but it is also involved in pathological conditions, like invasive migration of tumour cells leading to metastases. Conversion of stationary epithelial cells to invasive migratory cells involves changes in transcription, cytoskeletal organisation as well as signalling pathways. Cells can migrate either alone or as groups, both normally and in cancer. The migration of border cells during Drosophila oogenesis provides a powerful genetically tractable model to study developmentally regulated cell migration in vivo. We have developed an imaging method, which allows us to watch this migration process live. This allows us, in combination with genetic tools to study how group of cells moves as a unit. We have found, interestingly, that these cells move by two different modes. Initially the group of cells is lead by one cell, which pulls the rest of the cluster along. Later on, the cells take a more 'democratic' approach, and it seems that all cells are playing a role in deciding which direction to move. The two migration modes have quite distinct sensitivities to downstream signalling pathways of receptor tyrosine kinases and our results show that the difference in signalling levels between individual cells is used to guide the migration of the whole group. We are currently investigating how this difference in signalling is translated into effective migration.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Cell migration is needed during development of multi-cellular organisms, but it is also involved in pathological conditions, like invasive migration of tumour cells leading to metastases. Conversion of stationary epithelial cells to invasive migratory cells involves changes in transcription, cytoskeletal organization as well as cell signalling pathways.That specific transcription factors are required for cells to become migratory in each system where it has been investigated, emphasizes the importance of transcriptional changes. The migration of border cells during Drosophila oogenesis provides a powerful genetically tractable model to study developmentally regulated invasive cell migration in vivo. The aim of the study is to find novel genes regulating cell migration in order to better understand how cells become migratory in vivo.The proposed project is based on gene expression profiling (microarray) analysis of migrating border cells recently performed in the Rorth lab. The objective of the study is to identify putative regulators of cell migration by targeted gene silencing of candidate genes obtained from the micro-array analysis. The effect of gene silencing will be studied in three different migration models in Drosophila, namely border cells, hemocytes, and recently developed Drosophila model for tumour metastasis. In addition to novel insights into cell migration during development, the results obtained in this study have potential to further our understanding of genes and mechanisms involved in cancer metastasis.
Оригинален текст от CORDIS (на английски).
Участници
- EUROPEAN MOLECULAR BIOLOGY LABORATORY · HEIDELBERGКоординаторГермания
Връзки
Данни: CORDIS, © Европейски съюз