CAR IN COLON CANCER · Role of the calcium sensing receptor (CaR) in prevention of colonic hyperproliferation
6РП — Действия „Мария Кюри“
- Период
- 2007-04-01 → 2008-03-31
- Финансиране от ЕС
- 110 921 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Калцият в храната и неговият рецептор се изследват за това как ограничават деленето на раковите клетки в дебелото черво. Това помага да се разбере как приемът на калций може да намали риска от развитие на този вид рак.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - CaR IN COLON CANCER (Role of the calcium sensing receptor (CaR) in prevention of colonic hyperproliferation)
The major objective of this project was to clarify how dietary calcium might prevent colon cancer. Nowadays, at least one in five of the population of the world will develop a cancer of some sort. Therefore, its control and prevention are of utmost importance. Since several studies reported inverse associations between calcium intake and colorectal tumours, we concentrated our attention on studying the mechanisms by which calcium could perform this task. Using cancer cells, we were able to show that calcium indeed reduced the capability of these cells to divide. The method we employed, called microarray analysis, allowed us to discover several ways through which calcium could be beneficial in preventing the occurrence of cancer of the large bowel. Besides the mechanisms we had already thought of being influenced by calcium, like the cell cycle, we discovered several unexpected ones, e.g. those connected with protein degradation. These results opened up new research directions and would be the basis for further cooperation between Prof. Thakker, from the University of Oxford, and Dr Kállay, from the Medical University of Vienna. The already obtained along with our future data would allow us to give advice on whether and when it would be beneficial to take calcium supplements, which represent an easy, painless, effective and inexpensive way that could help to reduce the risk of colorectal cancer.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Since sporadic colorectal cancer (CRC) is, to a major part, preventable, attempts at primary prevention are rational, timely, important, and should be a major priority. Calcium was identified as a chemopreventive agent, since higher intake is associated with reduced risk of CRC. Mechanisms by which high calcium intake prevents neoplastic transformation in the colon are still poorly understood. We willevaluate the role of the calcium sensing receptor (CaR) in colon in calcium-dependent regulation of proliferation. CaR transduces variations in extracellular calcium concentration into modulation of signal transduction pathways involved in proliferation and differentiation, and its expression is lost during colon tumourigenesis. We will use the Nuf mouse model, which has an activating mutation of the CaR, and thus constitutes a unique model to study its role. We expect that the colon of Nuf mice will have increased sensitivity to calcium and will show lower expression levels of proliferation markers when receiving low calcium diet, compared with wild type littermates. In parallel we will investigate signal transduction pathways regulated by CaR in colonocytes. Results of this project would represent an important achievement in colon cancer chemoprevention, a disea se that causes a considerable socio-economic burden. Indeed, if the CaR has a central role in mediating the antimitotic effect of calcium, its expression in precancerous lesions or early colon carcinomas might have predictive value for identifying patients responsive to chemoprevention by calcium. The training program of the fellowship will provide the applicant with further qualifications for the development of an independent research career, will give her experience to lead a research group and will provi de contacts for future co-operations. Support of this fellowship would contribute to the promotion of European scientific excellence and would increase proportion of women involved in high quality science.
Оригинален текст от CORDIS (на английски).
Участници
- THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OXFORDКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз