PE-NANOSTRUCTURES · Spontaneous formation of nanostructures and responsive nanolayers by novel macromolecules and surfactants
6РП — Действия „Мария Кюри“
- Период
- 2006-03-15 → 2008-03-14
- Финансиране от ЕС
- 225 490 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Специални полимери с форма на четка и техните взаимодействия със surfactants се изучават за създаване на стабилни наноструктури. Те могат да помогнат при контролираното доставяне на вещества в организма или при създаването на повърхности, които предотвратяват имунни реакции.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - PE-NANOSTRUCTURES (Spontaneous formation of nanostructures and responsive nanolayers by novel macromolecules and surfactants)
The major goals of the project were based on a novel family of macromolecules called bottle brush polyelectrolytes. These are comb-like polyelectrolytes having a charged backbone with a high density of grafted neutral hydrophilic side chains. The project was aimed at exploring the dominant interactions and nanoscale organisation of these molecules in the bulk and at interfaces in the presence and in the absence of ionic surfactants. Polymer / surfactant systems are widely used in industrial formulations and every day products. Recently it has been realised that the polymer architecture can have a pronounced effect on both the bulk and surface properties of these systems. By tailoring the polymer structure novel functionalities and features can be developed. Our results indicate that due to the steric stabilisation provided by the grafted hydrophilic side chains, the bottle brush polymers can form uniquely stable complexes with oppositely charged surfactants and polyelectrolytes that may serve as delivery vehicles in controlled release applications. Work in this direction is currently in progress. We have also identified the optimal bottle brush composition as well as environmental conditions to provide maximum protection at solid surfaces against polyelectrolyte adsorption. This gives a possibility for the creation of self assembled 2D and 3D structures on surfaces that can be utilised in the preparation of nano-devices. Furthermore, we have demonstrated the effectiveness of the bottle brush polyelectrolyte adsorption layers to prevent protein adsorption, thus prevent the initiation of immune reactions. An additional objective of the project was to develop smart surfaces that can give fast and large response to environmental changes. Recently, there are considerable efforts in the literature to use temperature responsive nanogel particles for the creation of such surfaces. However, since the polyelectrolyte used to attach the nanogel particles to the surface can penetration into the gel beads, the response of these layers are strongly hindered. We were able to overcome this problem by covalently coupling the gel particles to the surface. Furthermore, we demonstrated that nanofibres can also be used to build up multilayer structures with nanogel beads. Since the fibres do not penetrate into the gel particles these assemblies are expected to have superior response and release properties compared to the ones that are formed by normal polyelectrolytes.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The major goal of the proposed project is to transfer the competences of the applicant to an interdisciplinary field of nanoscience (responsive and/or biocompatible nano-assembles and knowledge-based materials).To reach this goal the host will provide advanced training in several state-of-the-art surface characterization methods (e.g. surface force techniques like AFM and surface force apparatus, as well as QCM-D, ellipsometry and ESCA), with which the applicant has no previous experience and which are important tools of the targeted field. Furthermore, the applicant will gain research competences in a leading edge field of nano-science.The scientific program is based on a novel family of polymers (comb-like polyelectrolytes grafted with neutral hydrophilic chains) and divided into two work packages. The major goal of WP1 is to gain an understanding how the novel polymer structure affects the polymer/surfactant interaction in the bulk phase and at interfaces, thus providing the fundamental information needed to fine tune the structure of the novel polymers to specific applications. WP2 aims at the development of novel approaches to prepare biocompatible, patterned and responsive nanostructures needed e.g. in biotechnology and nanosensor assembly.Finally, the host will expose the candidate to the training of complementary skills that are essential to gain independence. Altogether, the project will complete and diversify the competences of the researcher which will enable him to start an independent career by initiating research in a new area of activity in his home institution in Budapest (which is in a less favoured region in a new member state of EU).Finally, since the researcher's home institution is a university, he will also be able to disseminate his newly developed competences, thus ensuring the transfer of knowledge to a wider audience, a constant flow of early stage researchers toward the ERA and thus the enhancement of EU scientific excellence.
Оригинален текст от CORDIS (на английски).
Участници
- KUNGLIGA TEKNISKA HÖGSKOLAN · STOCKHOLMКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз