SEMASNEUROPILINANGIO · The role of semaphorins and neuropilins in tumour angiogenesis
6РП — Действия „Мария Кюри“
- Период
- 2007-05-01 → 2008-04-30
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Ролята на протеините семафорини и невропилини при образуването на нови кръвоносни съдове в туморите се анализира чрез доставка на Sema3A с помощта на специални моноцити. Това помага за разбирането на механизмите за спиране на развитието на рака и търсенето на нови методи за лечение.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - SEMASNEUROPILINANGIO (The role of semaphorins and neuropilins in tumour angiogenesis)
Very little is known about the newly found receptor family of plexins, neuropilins and their ligands semaphorins in cancer progression and neo-angiogenesis. The evaluation of the inhibitory as well as positive function of different semaphorins, neuropilins and plexins are of great importance, which can lead to further studies to investigate the therapeutic possibilities of these molecules. Here, we show that semaphorin 3A (Sema3A) is a potential anti-cancer agent. A novel strategy - the tumour-homing ability of pro-angiogenic Tie2-expressing monocytes (TEMs) was exploited as delivery vehicles to transport Sema3A to the tumour site. By transplanting hematopoietic progenitors transduced with a Tie2 promoter/enhancer-driven Sema3A gene, we turned TEMs into Sema3A cell vehicles that efficiently inhibited tumour progression by inhibiting angiogenesis. The TEM cell mediated delivery proved to provide the system with the high efficacy and safety. These results illustrate the therapeutic potential of gene-based Sema3A delivery and treatment of cancer.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Very little is known about receptor family of plexins, neuropilins and their ligands the semaphorins, in cancer progression and neo-angiogenesis. There are over 20 different semaphorins and nine plexins that can interact with each other in various ways. This scenario implicates a complex signalling pattern, the evaluation of which has only begun. It has recently been suggested that semaphorins possess both attractory and repulsory effects, which most likely are mediated by specific adaptor molecules and receptor tyrosine kinases (RTKs). The evaluation of the inhibitory, as well as promoting, function of different semaphorins, neuropilins and plexins is of great importance, and may lay the framework for therapeutic applications of these molecules.This project is aimed at understanding the functional role and mechanisms whereby semaphorin and neuropilin signalling may regulate angiogenesis in pathological conditions, such as cancer progression with a specific focus on the down-steam signalling of the two receptors neuropilin 1 and 2. More specifically, the project will employ the highly effective lentiviral mediated gene transduction, as well as the novel technology based on haematopoietic bone marrow cells (TEMs) (De Palma 2003 and 2005). TEM cells will be transduced with the semaphoring/plexin/neuropilin of interest, which will then be injected into lethally irradiated mice, to allow for full engraftment of transplanted cells.By these means, the aim is to obtain chimeric animals bearing a bone marrow-derived cell population able to selectively target the expression of a tumour-arresting molecule into the tumour vasculature. We will also be able to use semaphoring and neuropilin knock-out mouse models for tumour studies in collaboration with Prof. Christer Betsholtz of the Karolinska Institut, Stockholm, Sweden and Prof. Anne Eichmann of the Collegé de France, Paris, France.
Оригинален текст от CORDIS (на английски).
Участници
- UPPSALA UNIVERSITY · UPPSALAКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз