PBR AND APOPTOSIS · Physiological role of the peripheral benzodiazepine receptor and its implications in apoptotic cell-death signaling pathways
6РП — Действия „Мария Кюри“
- Период
- 2008-03-03 → 2009-03-02
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- ERG
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Периферният бензодиазепинов рецептор (PBR) в митохондриите се изследва за това как влияе върху сигналите за клетъчна смърт. Разбирането на този механизъм помага за разработването на нови подходи при лечението на ракови тумори.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The peripheral benzodiazepine receptor (PBR) is an 18-kDa protein receptor, mainly found on the outer mitochondrial membrane of cells. The PBR seems to play a role in several cellular functions, including heme synthesis, steroidogenesis, DNA synthesis, cell growth and differentiation.Recently, a role for PBR in apoptosis has also been proposed and a number of findings argue in favour of this:- over-expression of PBR has been described in a large range of human cancers;- regulation of programmed cell death has in mitochondria a check-point targeted by various conventional cancer therapies; and- PBR ligation by directed drugs, enhances apoptosis induction in many types of tumours, reversing the Bcl-2 cytoprotective effects.These findings promoted the development of PBR targeting approaches in treatment of human cancers. Even though experimental data suggest that PBR may play a key role in various physiological and pathological processes, very little data are available on the protein-receptor cell physiology and on its role in apoptotic cell-death signalling pathways.OBJECTIVES: Our aim is then to investigate these aspects, studying the PBR capacity to modulate and shape the cell signalling, principally in respect of the mitochondrial function.In detail, we will:- examine the PBR expression and localization in cells of interest;- generate by molecular biology techniques recombinant probes of PBR;- investigate the result on cell signalling pathways of the PBR genetically and pharmacologically modulation;- finally, asses PBR role in respect of the apoptotic cell death and tumourigenesis.
Оригинален текст от CORDIS (на английски).
Участници
- DEPARTMENT OF EXPERIMENTAL AND DIAGNOSTIC MEDICINE UNIVERSITY OF FERRARA, ITALY · FERRARAКоординаторНиво градИталия
Връзки
Данни: CORDIS, © Европейски съюз