CARBOMETCOM · Carbohydrate metal complexes as photo chemotherapeutics and radiotracers for the treatment and visualisation of cancer
6РП — Действия „Мария Кюри“
- Период
- 2004-06-06 → 2005-12-05
- Финансиране от ЕС
- 149 338 €
- Участници
- 1
- Схема
- OIF
Линиите свързват координатора с партньорите.
Накратко на български
Метални комплекси, комбинирани със захари, се тестват като средства за разпознаване и унищожаване на ракови клетки чрез светлина или радиоактивни изследвания. Това помага за намаляване на токсичността на лекарствата и подобряване на точността при визуализирането на туморите.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - CARBOMETCOM (Carbohydrate metal complexes as photo chemotherapeutics and radiotracers for the treatment and visualisation of cancer)
The project was carried out to combine useful properties of carbohydrates and special metal complexes. Appending a carbohydrate has the ability to reduce toxicity, to improve solubility and opens up the possibility of molecular targeting of carbohydrate binding domains. Joined with special properties of selected metal complexes this should lead to materials with new features and novel kinds of application especially for the visualisation and treatment of cancer. The first aim was to create sugar substituted ruthenium complexes in order to use the unique properties of this metal (fluorescence, photo activity, coordination behaviour etc.) for the design of novel photo chemotherapeutics. We succeeded to synthesise complexes with 'ball like' shape completely surrounded by different sugar residues. We could show that these compounds are able to produce singlet oxygen under irradiation. But the most remarkable result is that tests against different cell lines including cancerous cells show a significant differentiation between certain cells strongly depending on the character of sugar substitution. For future investigations this raises hope to find carbohydrate substituents which introduce a high selectivity for certain cells. The second aim was to synthesise novel carbohydrate depending rhenium and technetium complexes and to study them as possible radiotracers for SPECT imaging. Two new types of Re and Tc complexes could be synthesised and structurally characterised. Experiments with the radioactive 99 mTc show the complete uptake of the nuclide and underline the high hydrophilicity of the formed compounds. Experiments concerning the stability of the formed complexes are still under investigation and the determination of a possible different distribution in tissue and body depending on the sugar substitution is considered. Beside this we could develop practical synthesis routs towards carbohydrate depending tripodal silver complexes. These compounds were tested against several bacteria, fungi and yeasts. They show a broad range of effective antimicrobial activities. The use of the carbohydrate based substances enhances the antimicrobial activity and reduces the cytotoxicity and antiproliferative activity compared to the free silver(I) salts and makes them suitable for possible antimicrobial applications.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The specific and multivalent saccharide-receptor interactions opens a new way of drug targeting to specific cells and introduction of very active metal complexes with a high potential for medical applications by unifying them with carbohydrate moieties. CARBOMETCOM includes two different approaches combining the positive attributes of both transition metal complexes and carbohydrates in order to achieve novel selective photo chemotherapeutics and contrast agents.The first concept is the synthesis of carbohydrate functionalised ruthenium complexes, which should be able to selectively infiltrate or bind onto cell surfaces depending on the type of sugar substitution. Novel coupling reactions for the formation of saccharide substituted metal complexes will be developed. The obtained complexes will be incubated with HeLa cells and their migration within this biological tissue will be detected.The second approach is the development of methods for the synthesis of novel tailor-made S-glycosides for the compexation of radioactive nuclides to create novel selective contrast agents. CARBOMETCOM will advance my competences particular in terms of multidisciplinarity and research management in the process of reaching a position of professional maturity and independence.Through the establishment of international collaborations I will consolidate and widen my career perspectives within the European Union. I will acquire knowledge and skills from the world leading group in the field of synthesis and characterisation of carbohydrate metal complexes and their application.The achieved results will open up new perspectives for selective drug delivery and development of new specific chemotherapeutics and contrast agents and provide the EU with new and competitive tools in the area of combating and imaging cancer as well as life science. This certainly meets the objectives of the FP 6 Combating Cancer (thematic priority 1.1.1).
Оригинален текст от CORDIS (на английски).
Участници
- FRIEDRICH-SCHILLER-UNIVERSITAET JENA · JENAКоординаторГермания
Връзки
Данни: CORDIS, © Европейски съюз