CARDICHIP · Development of a biochip to monitor cardiac wellness
6РП — Действия „Мария Кюри“
- Период
- 2006-08-01 → 2009-07-31
- Финансиране от ЕС
- 39 833 669 €
- Участници
- 2
- Схема
- TOK
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Биочипът CARDICHIP използва микроканали и капилярни сили за откриване на протеините C-реактивен протеин и NT-pro-BNP. Тези показатели помагат за по-точното проследяване и оценка на здравето на сърцето.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - CARDICHIP (Development of a biochip to monitor cardiac wellness)
Today most microfluidic devices consist of fluidic networks of closed channels and reservoirs. The Amic microfluidic platform for immunoassays relies on open channels and capillary forces for fluid distribution. In an infection moulded plastic device called the 4castchip(R) an open channel containing a highly ordered array of micropillars drives the liquid flow by capillary action, eliminating the need for any external liquid handling system. The flow rate can be controlled by altering pillar separation and geometry or by modifying the wetting properties of the chip surface. In a typical assay the test liquid is added to the sample zone. The micropillar array efficiently distributes the sample along the cdhannel to the detection zone, which contains immobilised capture antibodies. The analyte is captured and a fluorescence labelled detection antibody is flowed over the detection zone. The detection antibodies can either be predeposited in the channel and dissolved by the sample or added separately to the sample zone. Unbound detection antibody is washed away by the last part of the sample or by subsequent addition of a wash liquid. The last part of the channel, referred to as the wicking zone, also contains a micropillar array and is covered by a plastic film to avoid evaporation. In this project, the technology was advanced by: 1) developing a new way to prepare a suitable chip surface; 2) developing a way to efficiently collect emitted light; 3) develop a multiplexed assay for C-Reactive Protein and NT-pro-BNP, important analytes for assessing cardiac health.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The objective of the TOK project will be the development of a novel bio-diagnostic device, for the rapid and precise detection of a panel of 7 known risk factors for CVD. By monitoring these known risk factors it will be possible to detect the early stages of CVD before the appearance of clinical symptoms. This will allow doctors and patients to take preventative actions (therapeutic options or changes to lifestyle) to prevent the progression of/to CVD, resulting in reduced patient morbidity and mortality, allowing significant improvements in patient quality of life and longevity, keeping patients out of hospitals, and saving healthcare costs. The availability of this simple test for use in a doctors office or even in the home will allow for improved outcomes for patients, through early diagnosis and management of disease and offering a holistic approach to preventative medicine. The cardiac wellness biochip will integrate diverse technologies - multiple biological recognition, with highly sensitive signal generation and detection - onto a unique microfluidic platform. The resultant test will be easy to use, simple and cheap to manufacture and produce results in minutes. The test methodology will involve the addition of a small drop of blood from a finger prick onto the device.
Оригинален текст от CORDIS (на английски).
Участници
Връзки
Данни: CORDIS, © Европейски съюз