NEUROENDOCRINE COMMU · Cell communication between neural and endocrine systems
6РП — Действия „Мария Кюри“
- Период
- 2004-06-01 → 2005-05-31
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- ERG
Линиите свързват координатора с партньорите.
Накратко на български
Връзката между мозъка и хипофизата при рибите се анализира чрез проследяване на сигналите, които управляват стресовата реакция. Разбирането на тези процеси помага да се разберат механизмите при различни заболявания, свързани с неправилното функциониране на организма при стрес.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The vertebrate brain integrates information and governs the body via neural and endocrine communication systems. Because these systems should not convey conflicting messages, they must communicate with each other. The pituitary gland holds a key position in this integration, as it converts neural and neuroendocrine signals from the brain into endocrine signals.In this way, it controls a multitude of physiological processes, including the stress response. Malfunctions in the stress response communication hierarchy are involved in several diseases. To understand neuroendocrine integration, it is necessary to identify signal origins and receivers. At the level of the pituitary gland, such communication can best be studied in (teleost) fish, because, in contrast to mammals, the pituitary gland in fish is directly innervated by hypothalamic neurons.This project aims to map structural and functional relations between brain and pituitary cells in the stress response and to determine at what levels in the communication hierarchy signals are modulated to alter pituitary responses. The study focuses on fish brain slice preparations that contain both the hypothalamus and the pituitary gland, with their connections intact. First, the input and internal organisation of the hypothalamic nucleus preopticus (NPO), which projects the stress hormone CRH to the pituitary gland, will be neuroanatomically analysed.Next, CRH-cells will be electrophysiologically characterised by intracellular recordings, and labelled with biocytin to determine the contact types of CRH-cells on their pituitary gland target cells. Finally, the response of NPO CRH-cells to electrical and pharmacological stimulation will be assessed using electrophysiological techniques, and the subsequent pituitary endocrine output will be measured.
Оригинален текст от CORDIS (на английски).
Участници
- STICHTING KATHOLIEKE UNIVERSITEIT · NIJMEGENКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз