MICRODROPCAT · Application of Droplet-Based Microfluidics for the Screening of Supramolecular Catalysts
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2008-07-01 → 2009-12-31
- Финансиране от ЕС
- 157 733 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Микрофлуидните технологии се използват за създаване на нанокапки, в които се смесват химически компоненти за тестване на нови катализатори. Методът помага за по-бързото откриване на ефективни вещества, които ускоряват химичните реакции.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Application of droplet-based microfluidics for the screening of supramolecular catalysts
For this project we proposed to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Arrays of nanoliter-sized droplets containing complementary ligands will be merged together in a combinatorial fashion. These droplets will then be merged with a transition metal precusor to generate a 'catalytic' microdroplet. These 'catalytic' droplets will subsequently be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The MICRODROPCAT project proceeded according to the work plan detailed in part B of the grant proposal and to the career development plan. The key milestones until termination of the project have been met. The first year of this fellowship has been mainly devoted to acquiring the complementary skills in microfluidics, chemical engineering and spectroscopy necessary to carry out this project. In this respect, all of the training and transfer of knowledge needs established in the career development plan have been met. We have established a collaboration with Prof. M.T. Kreutzer (TU-Delft) who specialises in droplet-based microfluidics and who lends his micro-fabrication and chemical engineering expertise to this project. A second collaboration has been established with Prof. M. Bonn (AMOLF), an expert in spectroscopy, to use on-chip Raman spectroscopy for analysing the droplet content during the screening. Only a slight deviation pertaining to the technical solutions used for the generation of arrays of droplets and for the analytical technique to analyse reaction progress on chip have been made but the all of the main objectives are still being met. In the coming months, we will submit a publication on a novel catalytic system developed in part during this fellowship and which will be used in the microfluidic device. We believe the basic scientific and technical solutions for this ambitious project have been laid out and will serve as a good basis for their full implementation.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
In this project we propose to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Presently, the discovery and design of efficient homogeneous catalysts still relies on time intensive trial-and-error methodology. To overcome these limitations, a new paradigm shift for the discovery of effective ligands relies on the supramolecular self-assembly of libraries of ligand through reversible non-covalent interactions. This significantly increases the potential chemical space within which an optimal ligand set can be found. The full potential of this methodology is impeded by current synthesis and screening techniques which rely on macroscale (mL) trial for all the ligands sets and reaction conditions. One effective strategy to increase the rate at which reactions can be performed at is through extensive miniaturization of the reaction vessel. Recent advances in droplet-based microfluidics have enabled the effective screening of reaction conditions on a nano- to pico- liter scale. We thus propose to develop, in collaboration with a lab-on-a-chip research group, a modular droplet-based microfluidic device which will enable the generation, within a nanoliter droplet, of supramolecular catalyst made up of self-assembled ligands around a transition metal. These catalytic droplets will then be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The intended outcome of this project is to greatly accelerate the speed at which an active catalyst can be identified at. This will have a broad impact on the chemical community for which screening methodologies have become an integral part of the discovery process (e.g. drug discovery).
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITEIT VAN AMSTERDAM · AmsterdamКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз