EMERGENCE · Building a regulatory network for lateral root emergence
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2008-08-01 → 2010-07-31
- Финансиране от ЕС
- 178 307 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Молекулярните процеси при появата на странични корени, като действието на транспортния протеин LAX3, се анализират чрез 3D модели. Това помага да се разбере как растенията променят кореновата си система, за да се адаптират към почвата.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Building a regulatory network for lateral root emergence
Plants adaptation to soil necessitates a high level of plasticity of the root system. This developmental plasticity is achieved by the production of lateral roots in response to the environment. Lateral roots originate deep within the parental root from a small number of founder cells at the periphery of the vascular tissues and must emerge through intervening layers of tissues. Despite its importance to the integrity of the root system, little is known about the regulation of lateral root emergence. Recently, our lab identified that the auxin influx transporter LAX3 plays a key role in this process by regulating the expression of cell wall remodelling genes (Swarup et al., 2008). The EMERGENCE project aimed at identifying the molecular events underlying this process in order to build a multiscale model of lateral root emergence. The goal of our modelling approach was to: 1) build a network model of LAX3 induction in the cortical cells to determine if the actual network topology can explain the dynamics of LAX3 induction by auxin, 2) integrate the network into a realistic 3D geometry to characterise the spatial induction of LAX3 and 3) to determine whether our model could predict new important components of the LR emergence pathway.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Cell separation is a critical process for plants. Germinating seedlings emerge from their seed coats, anthers dehisce, fruit ripen, and organs are shed as a result of plant cell separation. To date, several cell wall remodeling enzymes associated with cell separation have been identified, however very little is known about the signals and mechanisms controlling their expression. The host laboratory has recently made major advances in the identification of the signals and molecular mechanisms regulating cell separation during lateral root emergence. The auxin influx transporter LAX3 allows the auxin inducible expression of a set of cell wall remodeling genes in front of the lateral root primordium to promote cell separation. The expression of these genes is dependant on the AUX/IAA proteins SLR1 and SHY2. The main aim of the present project is to study the signals and regulatory network that coordinates plant cell separation employing lateral root emergence as a model. I propose to adopt a Multidisciplinary Integrative Biology based approach which takes advantage of the facilities and expertise available in the host laboratory. Functional genomic, chemical genetic and mathematical modeling approaches will allow to identify new regulatory components and target genes then to build a regulatory network that will be modeled and tested.
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY OF NOTTINGHAM · NottinghamКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз