META-BREAST-CA · The role of intracrine receptor-ligand interactions in survival of disseminated breast cancer cells
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2008-12-01 → 2012-11-30
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-IRG
Линиите свързват координатора с партньорите.
Накратко на български
Генетично модифицирани мишки с биолуминесцентен маркер помагат за проследяване на развитието на рак на гърдата. Това позволява по-ранно и точно откриване на туморите, както и проверка на ефективността на нови лекарства.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
The role of intracrine receptor-ligand interactions in survival of disseminated breast cancer cells
Technology transfer opportunity Bioluminescent quantification of mammary tumour Development Opportunity: Novel research tool to early detect and quantify breast cancer progression in transgenic mouse models. Description of Technology: Homozygous mouse model expressing the luciferase reporter gene under the control of a mammary tissue-specific promoter (MMTV-Luc2 mice). The animals are suitable for cross-breeding with already existing strains or as a background strain for new models in order to evaluate the development and progression of mammary tumours. Value proposition: Conventional transgenic mouse models for breast cancer rely on palpation and mechanical measurement of tumour size and are hence unsuitable for early detection, monitoring and reliable quantification of tumour progression. Making use of readily quantifiable bioluminescence, the present mouse model allows for a sensitive and reliable assessment of spontaneous mammary tumours in genetically modified mice. The MMTV-Luc2 mice provide for a useful research tool to investigate breast cancer oncogenes/tumour suppressor genes and to test drug efficacies in the treatment of mammary tumours in transgenic animals. Main features: - Powerful technology platform for sensitive and mammary tissue-specific tumour visualisation using bioluminescence - Quantitative assessment of mammary tumour development in vivo - Low background - Simple cross-breeding enables assessment of oncogene of choice - Primary strain for new transgenic models for breast cancer Inventors: Dr Radoslaw Zagozdzon, Agnieszka Zagozdzon, and Prof William Gallagher, UCD School of Biomolecular and Biomedical Science, UCD, Belfield, Dublin 4 Publication: Manuscript in preparation Licensing status: Available for licensing Contact: Dr Claudia Wietek, Project Manager Technology Transfer, NovaUCD, Belfield Innovation Park, UCD, Belfield, Dublin 4% L t: 00-353-(0)1-7163722 e: claudia.wietek@ucd.ie w: http://www.ucd.ie/nova List of manuscripts with the contribution of the Fellow which have been submitted or are under preparation: Submitted: S. McGee, D.P. O'Connor, A.M. Zagozdzon, R. Zagozdzon, D.J. Brennan, A. O'Connor, J. Crown, A. Byrne, M.J. Duffy, W.M. Gallagher. Down-Regulation of SerpinB2/PAI-2 Promotes Breast Cancer Progression. (submitted to Cancer Medicine) Under preparation: 1. P.C. O'Leary, R.T. Dolan, S. Penny, C.M. Kelly, S. Madden, E. Rexhepaj, D.J. Brennan, A.H. McCann, F. Pontén, M. Uhlén, R. Zagozdzon, M.J. Duffy, M.R. Kell, K. Jirström and W.M. Gallagher. Systematic Antibody Generation and Validation via Tissue Microarray Technology Identifies a Novel 3-Protein Prognostic Panel in Breast Cancer. (target journal Breast Cancer Research) 2. P.C. O'Leary, D.J. Brennan, D.P. O'Connor, B.T. Hennessy, A.M. Gonzalez-Angulo, G.B. Mills, K Jirström, F. Ponten, J Crown, W.M. Gallagher, R. Zagozdzon. Peroxiredoxin-1 protects against oxidative stress-induced suppression of the estrogen receptor and is a biomarker of favourable prognosis in estrogen receptor-positive breast cancer. (target journal: Clinical Cancer Research) 3. A.J. Eustace, P. O'Leary, W.M. Gallagher, S. Rani, C. Gallagher, B.C. Browne, M. McDermott, L. O'Driscoll, R. Zagozdzon, W. Watson, J. Crown, N. O'Donovan. Acquired Sensitivity to TRAIL in lapatinib resistant HER2-positive breast cancer cell lines. (target journal Breast Cancer Research)
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Breast cancer is the most common cancer in women and, after lung cancer, the second leading cause of cancer-related deaths. The most important factor influencing the outcome of patients with an invasive cancer is whether the tumour has spread regionally or systemically. Breast cancer dissemination is a multi-step process, affected by intrinsic, as well as by microenvironmental factors. Metastases start out as single cells that detach from the primary tumour and travel to distal locations. The number of circulating tumour cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer. The biology of these cells is not well comprehended and its understanding is critical for therapeutic improvements. One of the key questions that remain to be fully resolved is what molecular events allow the survival of cancer cells in hostile environment of peripheral blood. Recently, a novel concept arose redefining the molecular basis of survival of breast cancer cells. According to this concept, tumour cells can utilize intracellular (intracrine) receptor-ligand interactions to produce signals necessary for tumour survival under unfavourable conditions. A major scientific objective of the proposed project is to generate, using a transgenic approach, the animal model systems of breast cancer allowing to study the role of intracrine signalling in survival of disseminating breast cancer cells. The work activities detailed in this proposal will have a significant impact on the understanding of the mechanisms of metastasis in early stage breast cancer and thus will facilitate the prevention and/or fight against metastatic breast cancer.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN · DublinКоординаторИрландия
Връзки
Данни: CORDIS, © Европейски съюз