FP7Реинтеграция2009–2011

NOTCH AND POLARITY · Modulation of the Notch receptor activity through the regulation of the epithelial apical-basal polarity in Drosophila melanogaster

7РП — „Хора“ (Действия „Мария Кюри“)

Период: 2009-01-01 → 2011-12-31
Финансиране от ЕС: 75 000 €
Участници: 1
Схема: MC-IRG

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между организацията на епителните клетки и работата на рецептора Notch се изучава чрез плодови мухи. Това помага да се разбере как разположението на протеините в клетката контролира развитието и специализацията на тъканите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Modulation of the Notch receptor activity through the regulation of the epithelial apical-basal polarity in Drosophila melanogaster

Several preliminary observations indicate that the apical-basal organisation of epithelial cells influence the activity of the Notch (N) signaling pathway. In Drosophila, N regulates fate decisions within epithelia that display a clear Apical-Basal Polarity (ABP). N and its ligands Delta (Dl) and Serrate (Ser) colocalise at the adherens junctions (AJ) level in epithelial cells, suggesting that signaling may take place at the AJ level in these epithelial cells. Studies in imaginal discs have shown multiple instances of modulation of N activity by ABP and AJ components like Crumbs or Par-1, DE-Cadherin, Echinoid or ZO-1.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Several lines of evidence suggest an interplay between apical-basal polarity (ABP) and Notch (N) signaling in epithelia. Available data indicate that modulation of N signaling can occur through both direct regulation of the activity and mislocalization of either the receptor or the ligand. The purpose of this project is to understand how N activity can be modulated by differential regulation of apical-basal components or, in general, subcellular domains. A genetic screen among genes involved in ABP, ranging from regulators of vesicular trafficking or protein sorting to polarity regulators themselves, will help us identify the components underlying this modulation. Further genetic analysis together with molecular biology and biochemistry studies will help understand the molecular mechanisms of N activity modulation by ABP. Both ABP regulators and N pathway members have been shown to be involved in crucial events during development and tissue homeostasis, such as control of epithelial integrity and cell division, that, when distorted, can lead to tissue overgrowth and eventually cancer. Nevertheless, the molecular mechanisms underlying these processes are very poorly understood. This project will help shed light on these mechanisms.

Оригинален текст от CORDIS (на английски).

Участници

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisКоординаторФранция

Връзки

Виж в CORDIS