THERMOMICS · Unraveling the functional architecture of the human thermoregulatory system through immunological, circadian and sensory mechanisms: focus on the mature European population
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2009-07-01 → 2013-06-30
- Финансиране от ЕС
- 100 000 €
- Участници
- 2
- Схема
- MC-IRG
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Терморегулацията при възрастни хора се анализира чрез измерване на топлинното съдържание в тялото, а не само на температурата. Това помага да се разберат механизмите, които водят до топлинен удар и смърт при екстремни горещини.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Unraveling the functional architecture of the human thermoregulatory system through immunological, circadian and sensory mechanisms: focus on the mature European population
Classical heat illness and death are major public health issues during exposure to heat stress for the elderly. Thousands of deaths among the elderly have been attributed to heat waves that have encompassed Europe in recent summers, while a higher frequency and intensity of heat waves is projected to lead to an increase in heat-related deaths as a result of global warming. The THERMOMICS project addressed several mechanisms that may explain the sequence of events leading to heat stroke and death. The project’s objective was to identify whether the regulated index of human thermoregulation is temperature- of heat-based. The THERMOMICS experiments aimed at applying thermal stimuli in different bodily systems while making precise time-based measurements of temperature at different body areas as well as total body heat storage. This procedure generated evidence suggesting that the observed responses in each system correspond more appropriately to alterations in heat content and only to a lesser extent in temperature. Thermoregulation-related mortality is a significant public health issue even in temperate to warm climates. Several papers on these issues have been published based on the research conducted in THERMOMICS. Therefore, the benefit from the THERMOMICS research is noteworthy because it has increased our understanding of the pathophysiological mechanisms related to thermal stress and it has related the progressive changes in the thermal strain to inflammatory responses, and effects on the circadian rhythm and the sensory system.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Thermoregulatory abnormalities are major public health issues during exposure to heat stress, particularly for the elderly. Thousands of deaths among the mature have been attributed to heat waves that encompassed Europe recently, while an increase in heat-related deaths is projected due to global warming. Exertional heat illness and death among highly motivated athletes and soldiers also occur frequently, particularly since the deployments of European soldiers to Afghanistan and Iraq. The current proposal addresses mechanisms that may explain the sequence of events leading to heat stroke and death. The project’s main objective is to identify whether the regulated index of human thermoregulation is temperature- of heat-based by applying thermal stimuli in different bodily systems while making precise time-based measurements of temperature and heat storage. Apropos, the letters ‘ICS’ in the proposal’s acronym ‘THERMOMICS’ indicate the immunological, circadian and sensory systems that will be investigated, while ‘M’ refers to the mature population that the novel knowledge will be applied to. The potential benefit from this research is vast because it will help us understand the pathophysiological mechanisms related to thermal stress and relate the progressive changes in the thermal strain to inflammatory responses, and effects on the circadian rhythm and the sensory system. The fellow researcher has a true thirst for scientific research and is a highly accomplished individual at his stage of career development with the personal and intellectual qualities to thrive in any research environment. He has already received an Assistant Researcher offer by the host institution, a state of the art facility encapsulating pioneer researchers of high caliber. The thriving collaboration between the researcher and the host hitherto will guarantee a successful implementation of the fellowship.
Оригинален текст от CORDIS (на английски).
Участници
Връзки
Данни: CORDIS, © Европейски съюз