MACACA · Determinants of mandibular form during intra-oral food processing
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2010-12-01 → 2012-11-30
- Финансиране от ЕС
- 30 000 €
- Участници
- 1
- Схема
- MC-ERG
Линиите свързват координатора с партньорите.
Накратко на български
Формата на долната челюст се проучва чрез връзката между движението на устата, работата на мускулите и свойствата на храната. Това помага да се разбере как механичното натоварване при дъвченето влияе върху скелетната структура на челюстта.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Determinants of mandibular form during intra-oral food processing
A lot of attention has been paid to the morphological variations of the craniofacial skeleton and its adaptation to diet, but the study of the mandible and its relation to feeding behaviour lags behind. Whilst a combination of factors, not necessarily mutually exclusive, have been proposed as determinants of variation in mandible morphology (sexual dimorphism, facial orientation, dentition and phylogenetic constraints), most focus has been put on adaptation to mechanical loading during chewing. Chewing is a highly modulated behaviour during which the food particles are processed using the postcanine dentition till the size and texture of the bolus permit a safe swallow. Previous studies on primates have shown that variations with regards to the material, structural, and physical properties of the processed food particles, coupled with the location of the bite force influence the activation patterns and the force modulation of the muscles of mastication. The electromyographic activity of the muscles of mastication and in particular the peak amplitude and timing affect the jaw kinematics and in particular the variance in the duration of gape cycles, gape-cycle phases and displacement of the lower jaw not only between chewing cycles but also within and between feeding sequences. But what is the effect of jaw kinematics and muscle activity on the skeletal morphology of the mandible? This study uses an interdisciplinary approach to combine state of the art experimental, computer simulation and analytical techniques to investigate the function of the feeding apparatus during intra-oral food processing. Preliminary results show a high correlation between jaw kinematics, the activation patterns of the muscles of mastication, force modulation and the stress and strain magnitudes and orientations when consuming food particles of varying toughness. This correlation is affected by the bite location, chewing rates and different gapes. The results of our study offer a better understanding of the functionality of the feeding apparatus during intra-oral food processing and shed light to important biological questions regarding the sensitivity of the feeding variables to the toughness of the food items consumed and the location of the bite, hitherto obscured. The incorporation of our unique experimental data into computer simulations ensured the most precise, complete and validated study on the mechanical determinants of the mandibular morphology in response to diet and will become a landmark reference for future feeding biomechanics studies.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Whilst the biomechanical determinants of a chewing cycle are essential components of the primate feeding system from an evolutionary and a clinical perspective, lack of experimental studies have resulted in the construction of oversimplified and biologically inconsistent computer simulation models. Such models have been employed to answer hypotheses regarding feeding biomechanics and dietary ecology of extinct and extant species, leading to questionable results. This study applies the most complete bone strain, bite force, jaw optico-kinematic, and electromyographic data to a series of finite element models of a M. mulatta mandible to simulate a complete chewing cycle. The main objective is to estimate stress and strain concentrations on the mandible during molar, premolar and incisor biting when processing food particles that vary in their material properties. The accuracy of the FE models will be tested by conducting a series of sensitivity analyses regarding bite locations. The models will then be validated against experimental in vivo bone strain data. A series of statistical analyses will be also employed to study strain magnitudes and orientations in the primate mandible in relation to loading and unloading times, chewing rates, chewing frequencies and gapes. It is hypothesised that strain magnitudes, patterns and orientations will be highly sensitive to different biting cases and dependent on the food particles consumed and the chewing frequencies employed. The results will give new insights into the nature of the stresses and strains the primate mandible undergoes during a chewing cycle and will indicate how strong the mandible is in relation to the functional stresses it experiences. We will then, with unprecedented rigour, illuminate a level of mechanistic explanation of why many non-human primates in captivity develop pathologies in the mandible related to masticatory stresses and to an inappropriate diet.
Оригинален текст от CORDIS (на английски).
Участници
- THE ROYAL VETERINARY COLLEGE · LondonКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз