Mesendot · Regulation of mesenchymal stem cells by vasculature and enhancement of their regenerative potential for the treatment of acute myocardial infarction
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2011-04-01 → 2013-03-31
- Финансиране от ЕС
- 230 980 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Взаимодействието между мезенхималните стволови клетки и кръвоносните съдове се анализира, за да се разбере как те влияят една на друга. Това е важно, защото може да помогне за разработването на методи за възстановяване на сърцето след инфаркт.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Regulation of mesenchymal stem cells by vasculature and enhancement of their regenerative potential for the treatment of acute myocardial infarction
Heart failure remains one of the leading causes of morbidity and mortality. As the adult myocardium has insufficient regenerative capacity cardiac myocyte loss as a result of injury or disease is essentially irreversible. Therefore, individuals who suffer large acute myocardial infarction often progress to congestive heart failure. Despite significant advances in medical management, the prognosis of end-stage congestive heart failure remains very poor and the identification of mechanisms and potential therapeutic approaches for the treatment of myocardial infarction remains of considerable importance. Understanding the MSC niche will provide a framework for the elucidation of stem cell function and regulation and for their successful use in regenerative medicine. In this project, we will analyse communication of MSCs with their microenvironment in a bidirectional way, considering not only the cues that MSCs receive from the endothelium but also the effect of the stem cells on angiogenesis and endothelial differentiation and function. The project aims to study the MSC vascular niche as a dynamic and interactive unit and to determine the molecular mechanisms that regulate its homeostasis and function. The knowledge acquired with this project will give us the opportunity to develop adult stem cell-based techniques for myocardial regeneration.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Mesenchymal stem cells (MSCs) can contribute to the regeneration of different tissues by differentiating into a wide variety of cell types, including cardiomyocytes, adipocytes and endothelial cells among others. MSCs represent a reliable source of adult stem cells in humans. A recent report suggests that MSCs concentrate around blood vessels, although the MSC natural microenvironment (niche) is not completely understood.In this project, we aim to study the biology of Bone Marrow derived stem cells (BM-MSCs) and Adipose tissue-derived mesenchymal stem cells (ASCs) in their niche and exploit this knowledge for the treatment of myocardial infarction. We will analyze the interaction of these two types of MSCs with blood vessels, identify the molecules involved and compare which one is more effective for cardiac regeneration. Objectives: 1) Determine the effect of blood vessel-derived cells on human and mouse MSCs; 2) Define the interactions between MSCs and blood vessel-derived cells in the human and mouse MSC niche, including the identification of the molecules mediating direct cell contact and the soluble factors mediating the paracrine effect of blood vessels; 3) Determine the role of the identified factors in the MSC niche in vitro and in vivo by using recombinant proteins and neutralizing antibodies; 4) Compare the potential of BM-MSCs versus ASCs for myocardial regeneration and repair, and investigate the capacity of the identified factor s to enhance this potential. The results will contribute to the development of novel therapeutic strategies for the treatment of myocardial infarction.The project will provide specific training for the researcher in the field of human stem cells, cardiovascular research and general issues related to clinical as well as basic human research that will help the transition of her career into translational research.
Оригинален текст от CORDIS (на английски).
Участници
- SERVICIO MADRILENO DE SALUD · MADRIDКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз