NANOTESTS · Fabrication and development of nanotoxicology-test bacterial arrays for the investigation of antibiotics against multi drug-resistant bacteria
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2012-03-01 → 2015-02-28
- Финансиране от ЕС
- 223 670 €
- Участници
- 1
- Схема
- MC-IOF
Линиите свързват координатора с партньорите.
Накратко на български
Хартиени сензори с нанопокритие се разработват за тестване на антибиотици срещу бактерии, устойчиви на лекарства. Тези евтини устройства помагат за по-лесна клинична диагностика и мониторинг на околната среда, дори в развиващите се страни.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Fabrication and development of nanotoxicology-test bacterial arrays for the investigation of antibiotics against multi drug-resistant bacteria.
The final “Nanotest” devices based on the treatment of paper with different fluorinated silane groups developed within the project have the potential to provide control on biomedical fluid handling in 3D, an inexpensive platform for clinical diagnostics, a human-like environment to run toxicological assays o environmental monitoring. Embossed paper-based “Nanotests” are a new class of point-of-care diagnostic devices that are inexpensive, easy to fabricate in large quantities, and appropriate to be used by inexperienced users in developing countries.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Bacterial resistance to antibiotics is one of medicine's most vexing challenges. Most antibiotics initially work really well, killing more than 99.9% of microbes they target. But through mutation and the selection pressure exerted by the antibiotic, a few inevitably manage to survive, and flourish as antibiotic-resistant strains. Hence, new strategies to design antibiotic to combat drug-resistant bacteria are required. Many drug delivery systems based on nanomaterials have been developed during the last decade, being the toxicology of these materials into single bacteria still not thoroughly evaluated due to the lack of reliable techniques to confine individual microbes. Prof. Whitesides' group in Harvard University (USA) is undoubtedly a world leader in this area, as it has a high international profile earned through many key contributions about novel nanofabrication methods for microbiological applications during the last 20 years. Prof. Miranda and Prof. Carrascosa (both from IMDEA Nanoscience-Spain) are the leaders of research groups working in collaboration for (i) the development of novel antibiotic strategies based on drug delivery nano-systems and (ii) biophysical aspects of cell mechanics, self-assembly properties of organic heterostructures and supramolecular nanomachines. The time is ripe to integrate the various strategies developed by Prof. Whitesides’ group to confine single living bacteria with the novel strategies for drug delivery that are being developed at IMDEA Nanoscience-Spain.The aim of the present OIF includes consolidating IMDEA expertise in the toxicological effect of nanoparticle based drug carriers into individual bacteria in order to develop a novel set of antibiotics for treatment of multi drug-resistant bacteria and to contribute to fundamental questions about bacterial biology, such as cell wall biophysics, chemical bonding and DNA conformational dynamics.""
Оригинален текст от CORDIS (на английски).
Участници
- FUNDACION IMDEA NANOCIENCIA · MadridКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз