Bio-MAPS · Bio-mimetic Multi-functional Active Porous Structures
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2011-09-01 → 2014-08-31
- Финансиране от ЕС
- 75 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Математически алгоритми създават сложни 3D модели на порести структури, които имитират живи тъкани за биопринтиране. Тези методи подобряват растежа на клетките и помагат за по-точното изграждане на изкуствени тъкани и органи.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Bio-mimetic Multi-functional Active Porous Structures
The objective of this research work is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures for tissue engineering and 3D Biopirinting. The main objective of BIO-MAPS project is to develop novel methods and algorithms to design active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements. The designed models are then used to control 3D bioprinting processes to fabricate designed scaffolds directly from developed computer models. The developed methods in this period makes more advanced multi-functional tissue scaffold possible. With the developed designed strategies, these developed multi-functional porous structures could be used to provide biological and other functionalities in 3D configuration. The developed reproducible and controllable internal architecture design methods could enhance the cell in-growth while forming the desired tissue structures. The developed algorithms and methodologies advance the knowledge and the literature in computer-aided design (CAD) of heterogeneous porous scaffolds and 3D additive manufacturing and bioadditive processes. The developed algorithms can be used to design heterogeneous porous scaffolds for not only tissue engineering but also other applications of porous and multi-material structures. In addition, developed multi-nozzle bioadditive processes capable of printing biomaterials with controlled micro-architecture. The results from this research enables 3D bioprinting of not only biomaterials but also with live cells. The impact of these research will be high by enabling 3D tissue and organ printing with live cells.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The objective of this research plan is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures with controlled material composition and distribution. The proposed work will be used to model active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements.First, computational algorithms are proposed to optimally design multi-material with bio-active molecules spatially in porous structures. A new design methodology is proposed to relate material and bioactive distribution to 3D shape (geometry). The internal micro-architecture of porous structures is also optimized based on biological and mechanical requirements. Second, a novel bio-fabrication processed is proposed to fabricate designed multi-functional active porous structures with various biodegradable materials embedded with active bio-molecules directly from the computer models. The proposed methodologies will be applied to 3D tissue scaffolds. Cell migration into design 3D scaffold will be tested in-vitro to assess and optimize the proposed methodologies. The proposed methods will make more advanced active scaffold systems possible. These active multi-functional porous structures could be used to arrange cells in an appropriate 3D configuration and present molecular signals in a spatial and temporal fashion so that the individual cells will grow and form the desired tissue structures.The results from this research would enable use of active implants, tissue/organ substitutes and micro-scale bio-sensors in many new applications in medicine and biomedical engineering. This project will also advance the knowledge in heterogeneous object modelling in computer-aided design, layered-based fabrication methodologies and biomaterials.
Оригинален текст от CORDIS (на английски).
Участници
- SABANCI UNIVERSITESI · IstanbulКоординаторТурция
Връзки
Данни: CORDIS, © Европейски съюз