IONOMIC VARIATION · The Genetic Basis and Adaptive Significance of Natural Ionomic Variation
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2011-09-01 → 2015-08-31
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Генетичните разлики при растението Arabidopsis thaliana определят как то усвоява и разпределя минерали и микроелементи в корените и листата си. Разбирането на тези механизми помага за адаптацията на растенията към почвата и подобрява качеството на култури като ориза.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
The Genetic Basis and Adaptive Significance of Natural Ionomic Variation
Prof Salt has used genome-wide association (GWA) mapping to take advantage of the natural genetic diversity of Arabidopsis thaliana to allow the testing of multiple allelic variants of genes across many thousands of loci to perform a truly genome-scale analysis of function. This approach helps to overcome the problem of low throughput associated with assigning gene function using reverse genetics to test one gene at a time. Using such a genome-wide approach Prof Salt has identify loci that play an important role in regulating mineral nutrient and trace element uptake, translocation and accumulation in roots, leaves, and seeds from A. thaliana. The identification of natural allelic variants of genes that regulate the mineral nutrient and trace element content (aka ionome) of A. thaliana has also allowed Prof Salt to investigate the role these alleles play in the adaptation of A. thaliana to the varied edaphic conditions this species experiences across its broad and diverse habitat. This project has provided a foundation of basic knowledge on mineral nutrient homeostasis in plants, and allowed us to start to understand how natural variation in the genetic networks that regulate the ionome are involved in adaptation to varied edaphic factors. This information has started to be translated in rice to better facilitate improvements in crop performance and quality. To help in both the discovery of this information by the community and to assist in its dissemination the IonomicsAtlas web-based tool has been developed and intergrated into the Ionomics Hub (iHUB) that Prof Salt manages at www.ionomicshub.org.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Evolutionary forces are known to drive the fixation of locally adaptive genetic variation within populations, and plants provide an excellent model for investigations into its genetic origins, maintenance and adaptive significance. We aim to take advantage of the natural genetic variation that occurs between populations of the genetic model plant Arabidopsis thaliana to identify gene functions that vary between these natural populations. Such a set of polymorphic genes and gene functions will provide the essential tools required to uncover the genetic mechanisms that drive the fixation of locally adaptive genetic variation within a population. To link natural genetic variation to function, we have applied high-throughput Inductively Coupled Plasma – Mass Spectroscopy (ICP-MS) based elemental-profiling, in combination with genome-wide association mapping and traditional linkage mapping to reveal loci that drive natural variation in the plant's elemental-profile or “ionome” including P, Ca, K, Mg (macronutrients); Cu, Fe, Zn, Mn, Co, Ni, Se, Mo, I (micronutrients of significance to plant and human health); Na, As, and Cd (minerals causing agricultural or environmental problems). Using a combination of laboratory and field-based experiments we propose to uncover the adaptive benefit and evolutionary significance of these naturally occurring polymorphic ionomic loci, along with their molecular function, and underlying causal genetic and epigenetic basis. This information will help determine the evolutionary processes involved in adaptation of organisms to local environments. Such insights will help in predicting the extent and limits of possible future adaptations of plants to changes in the surface chemistry of the Earth driven by a changing global climate, and will have applications to optimizing the mineral content of food crops for improved human health. After all, plants provide the major source of nutrition for a large portion of the world’s population.
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN · AberdeenКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз