mutation

DeepGlue · Deep mutational scanning of target protein resistance to molecular glues

EvoZyme · Development of a synthetic diversification platform for targeted EVOLUTION of ENZYMES supporting a sustainable bioeconomy – EvoZyme

LivAdapt · Transcriptional adaptation during vertebrate development at the single-cell level

Epi-IBD · Using an organoid model to understand epithelial immunity in IBD

BIOSMALL · Identification of subtype-specific biomarkers in small cell lung cancer

7 партньори · 5 държави

CADASIL-iMATTR · Investigation of Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy (CADASIL) using induced pluripotent stem cell modelling and targeted therapeutic research

3 партньори · 2 държави

FIXNALCN · Exploring neuronal functions of NALCN in health and disease

BIFCOLC-QS · Quorum sensing as a tool to detect and target pro-oncogenic microbial biofilms associated with right-sided colorectal cancer

IDP Assembly · Novel Integrated Approach for Assembly Analysis of Intrinsically Disordered Proteins at High Resolution

NERVSPAN · Molecular Dynamic of Neurons during C. elegans Lifespan

18 партньори · 7 държави

EvoBias · The role of developmental biases on the tempo of phenotypic evolution

SpecDroHuman · Impact of α-spectrin mutations on the cytoskeleton and organelle organization in neurodegeneration

IDPro · Intrinsically disordered proteins in health and disease: mechanisms, molecular context and opportunities for drug discovery

14 партньори · 7 държави

MOVINGHEART · How pathological mutations and drugs alter the intracellular movements of the cardiac sodium channel (Nav1.5).

MICROCOSMS · Exploring microbial community stability across mutational spectra

2 партньори · 2 държави

DRIMMS · Dissecting the role of the immune microenvironment in the onset of myelodysplastic syndromes

MMM · Medicine Made to Measure.

23 партньори · 8 държави

CohesiNet · Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases

22 партньори · 9 държави

ACCURACY · Human cardiac microtissues for studying lamin cardiomyopathy

MITO-GARAGE · Deciphering the Roles of the Salvage and De Novo Pathways of Nucleotide’s Metabolism in Mitochondrial DNA Maintenance

2 партньори · 2 държави

PARTHECOM · New pathway and small-molecule compounds for Parkinson’s disease therapy

2 партньори · 2 държави

CombGeneTher · Gene-Independent Combination Therapy for Rod-Cone Dystrophy

HYPOXIA · Highlighting Novel Mechanisms SwaYing ErythroPOietin EXpressIon and RegulAtion

IronKiller · Joining the forces of Natural Killer Cells and Ferroptosis to treat Refractory Neuroblastoma

2 партньори