medicinal chemistry

COMPUT DRUG DESIGN · Targeting the mutated PI3Kα isoform for the development of novel anti-cancer agents

STARS · Scientific Training in Antimicrobial Research Strategies

7 partners · 5 countries

CYCLOTIDE MECHANISM · Elucidating the mechanism of action of cyclotides: ultra-stable proteins from plants

STOADA · Synthesis of Targeted Organometallic Anticancer Drugs and their mode of Action

PEP2BRAIN · Selected peptides as drug candidates directed to pain and neurodegeneration

5 partners · 3 countries

AR BF3 BINDERS · Identification of the protein binders of the androgen receptor BF3 pocket, an allosteric modulator of AF2 coactivator recruitment

TOPCRYST · Novel tools for crystallisation of macromolecules

3 partners · 2 countries

MTDI-DNA · Molecular Theory of Drug Intercalation into DNA

DRUG-DISCOVERY · Synthesis and screening of new small molecules with antibacterial activity: Discovery of novel biological targets

PHYTOPHARM · Phytochemical and Pharmacological Study of Plants Used in Traditional Medicine in Cameroon

MODELING PH-DEPENCE · Modelling pH-Dependence in rational drug design

SPIROTENUIPESINES · Total Synthesis of the Potent Neurotrophic Factors Spirotenuipesine A and B

2 partners · 2 countries

P53MUT. REACTIVATORS · Computer-assisted drug discovery and biophysical characterisation of mutant re-activators of the transcription factor p53 as putative tumour therapeutics

PLK1 INHIBITION · Inhibition of Cancer by Disrupting Interaction Between Polo-like Kinase 1 Polo-box Domain and Spindle Targets

BIOMEDCHEM · Training for new approaches in anti-parasite and anti-tumour drug discovery

MEDCHEM AT QUB/GSK · New methodologies to synthetise unnatural nucleosides, known and putative antiproliferative agents

COMBINE-ENGINEER · A software tool for molecular design using protein structure-based quantitative structure activity relationships

PHARMAMAL · Investigation of the mechanism of action of antimalarial agents, by means of computational methods. Bases for the rational design of new antimalarial drugs

POLYKETOMACROCYCLES · Transannular Macrocyclisation and the concise total synthesis of Antifungal natural products

FOLDAMERS · Design, synthesis, Structural Characterization and biological evaluation of new peptidomimetics with a defined secondary structure

3 partners · 3 countries

SMARTSCREEN · Magnetic resonance in drug screening

4 partners · 4 countries

MET-CANCER THERAPY · Animal models and drug design for therapy of cancers induced by the oncogene, met

NAC-DRUG · Nucleic Acid Based Drug Design Training Center

MALKIN · Targetting malarial cell cycle kinases