oncology

HCV-PARP · Study of inflammation on a murine model of HCV

CASTEMHEDGEHOG · The role of stem cells in cancer development in skin and mammary gland using tissue specific expression of Gli1 protein - main effector of the hedgehog signalling pathway

PROTEUS · The role of the intracellular peptidases in the immune system and in the cellular metabolism

CHAIRDIS · Chitinase and chitinase-like proteins in airway disease

ANTICANCER · Elucidation of the molecular basis of the inhibition of microtubule dynamics

TRGE-ZEB-IRG · Transcriptional regulation of gene expression during cell differentiation and oncogenic transformation

LY49-AUTOIMMUNITY · Regulation of immune responses and autoimmunity by activating and inhibitory NK receptors expressed by T lymphocytes: role of ITAM versus ITIM signal balance

CELL MIGRATION · Identification and characterization of novel genes regulating cell migration

SKI IN SCHWANN CELLS · Functions of the proto-oncogene Ski in the regulation of TGFbeta signalling and the control of Schwann cell proliferation, differentiation and apoptosis

NEURAL PROLIFERATION · From stem cell to neuron: Understanding the genes that regulate the balance between proliferation and differentiation in the retina

SPIROTENUIPESINES · Total Synthesis of the Potent Neurotrophic Factors Spirotenuipesine A and B

2 partners · 2 countries

P53MUT. REACTIVATORS · Computer-assisted drug discovery and biophysical characterisation of mutant re-activators of the transcription factor p53 as putative tumour therapeutics

GENETIC BARCODING · Determining the relationships between haematopoietic lineages using genetic barcoding

ANTILEUKEMIA T CELLS · Redirecting Cytotoxic T Lymphocytes towards Leukemic antigens

MOUSE MELANOMA MODEL · Characterization of novel acting mechanisms of the Hepatocyte Growth Factor (HGF) in melanomagenesis: Bring into play the HGF transgenic animal model

3DCAP · Three-dimensional genomic analysis of cancer progression

HCVCORE2005 · Molecular characterization of the HCV core protein mobility to/from lipid droplets and its role in their formation

PEPTIDE QUANT · Quantification of bioactive peptides by mass spectrometry - Applicability in drug discovery

PLK1 INHIBITION · Inhibition of Cancer by Disrupting Interaction Between Polo-like Kinase 1 Polo-box Domain and Spindle Targets

ACG-ANTITUMOUR · Design, synthesis and biological studies of novel 1,4-benzoxazepines as antitumour compounds

GADD45 AND P38 · Role of the p53-effector gene Gadd45 as tumor suppressor and/or autoimmune disease suppressor gene

PHARMACODIAGNOSTICS · Pharmacodiagnostics for prediction of breast cancer treatment

GI CANCER · The role of interaction between gastrins and peroxisome proliferator-activated receptor gamma in gastrointestinal cancers

RECEPTEUR · Cytokine receptor traffic, signalling and human disease

9 partners · 7 countries