медицинска химия

MACROIMAGING · Specific Fluorogenic Peptides for Imaging Metastasis-associated Macrophages

silvercatpharma · from gold to silver: streamlining metal-catalysed cross-coupling reactions

MBLIs · New Approaches to Metallo-β-Lactamase Inhibitors

Amine-FUNC · Amine-Directed Diverse C(sp3)-H Functionalization

ISOTRAPSS · Isoform specific inhibition by transient protein state stabilization

Bump-BET · Bump and Hole approach to elucidate function of individual bromodomains of BET proteins

FAST-RAP · Structure-function studies of the human FASTK family of mitochondrial proteins with putative novel RNA binding domains – the helical FAST motifs and the small RAP domain

Pharmcophore-DOS · Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2

INTEGRATE · Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

14 партньори · 8 държави

ANTIVIRALS · European Training Network on Antiviral Drug Development

13 партньори · 7 държави

MAGICBULLET · Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy

14 партньори · 4 държави

MEMBRANELIPIDTHERAPY · Membrane lipid composition as new antitumor therapeutic target: sphingomyelin synthase (SGMS) at the basis of Minerval® mechanism of action and design of new Minerval®-related drugs

NEUPROTALL · The role of neutrophils and their proteases in the pathology of allergic airway disease

POL2-CCR · Structure-function analysis of mRNA metabolism by Ccr4-Not

orthoPROTACS · Design of orthogonal molecular probes targeting engineered von-Hippel Lindau (VHL) E3 ubiquitin ligase for the control of intracellular protein levels

HKMTIs · Computer-aided Design and synthesis of inhibitors of EED-EZH2 interaction as a novel approach for anticancer therapy

mechFXR · Towards FXR-mediated therapeutic intervention: Understanding how FXR integrates metabolic, endocrine and inflammatory signaling

Synapses FXS · Characterization of the molecular components of synapses in Fragile-X mental retardation syndrome: new insights into the FMRP regulatory mechanisms

TN-SEQ · Identification of genetic determinants involved in Streptococcus pneumoniae pathogenesis

MolecularDoctors · RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer

ICSTH · An Integrated Computational and Spectroscopic Investigation of the Enzyme Mechanism of Tryptophan Hydroxylase

NAPE-PLD · Structural and functional insight into the biosynthesis of endogenous lipidic messengers by the N-Acyl Phosphatidylethanolamine Phospholipase D (NAPE-PLD)

COSPRODYN · Computational Studies of Proton Dynamics in Hydrogen Bonded Systems and Enzymes

ALOE-DIVERSITY · Phylogeny and ethnobotany: Testing predictive approaches to plant drug discovery in the genus Aloe L. (Asphodelaceae)