mutation

FANCODRUG · Reactivation of the Fanconi anemia-BRCA pathway in cells carrying patient-derived missense mutations: finding a drug to cure Fanconi anemia

LungCARD · Blood test for clinical therapy guidance of non-small cell lung cancer patients

17 партньори · 14 държави

DNAREPAIRMAN · Regulated Assembly of Molecular Machines for DNA REPAIR: a Molecular Analysis training Network

13 партньори · 5 държави

TRANSMIT · TRANSlating the role of Mitochondria in Tumorigenesis

14 партньори · 7 държави

MARS · Mechanism of allosteric regulation of SHP2 phosphatase and its role in cancer and genetic diseases: a multidisciplinary computational, structural and biological approach

PCFENCM · Pan-cancer functional evaluation of non-coding DNA mutations

2 партньори · 2 държави

DMD2CURE · Correction of duplications in the DMD gene by a CRISPR/Cas9 approach

EpiTarget · Epigenome-targeted therapy for cholangiocarcinoma.

REPROHEAT · Increasing reproductive success in crops under high ambient temperature

Wnt and CRC · Therapeutic inhibition of the oncogenic Wnt/beta-catenin pathway in mismatch repair deficient hypermutant tumors

EvolVir · Evolution of virulence in immune-compromised hosts and the adaptation of emerging viruses

iGEMMdev · Development and Characterisation of New Immunogenic GEMMs of Lung Cancer

ADAPTATION · Predicting adaptive responses of protected species to environmental changes to optimise conservation management frameworks in Europe

BRAIN REPEATS · Repeat polymorphisms as genetic modifiers of brain function in healthy subjects and Huntington disease mutation carriers

SYNTRAIN · Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network

13 партньори · 9 държави

TransSplicHD · Single-Cell Transcriptomics and Spliceosome analysis to uncover new mechanisms of neuronal vulnerability to Huntington’s Disease.

YRNAcleave · Sequence and structural requirements for Y RNA cleavage

WntELECT · Wnt Enhancer LandscapE CharacTerization

MITOBIOPATH · DISCOVERING NEW DISEASE PATHWAYS AFFECTING mtDNA METABOLISM

2 партньори

ROQ-WACh · Identification and Characterization of Cis-Regulatory Module Dysfunction in Rett Syndrome with ROQ-WACh

NuSiCC · Modelling the therapeutic potential of NUAK1 suppression in colorectal cancer

DNA Pol III · How single DNA polymerases make decisions during proofreading

SynGenes · Defining the genetics of grapheme-colour synaesthesia

DynOMIS · Dynamic Origins of MHC class I Selector function